Optimal powder flow is essential in almost all pharmaceutical processes. Not only in unit operations involved in the production of solid dosage forms such as tableting, capsule filling and roll compaction, but also for processes used to produce liquid or semi-solid preparations. Poor flow can lead to processing problems, e.g. inconsistent feeding, air entrainment, but more importantly also to rejections due to compromised dosage uniformity. Active Pharmaceutical Ingredients (APIs) in particular often exhibit poor flowability. Multiple factors contribute to poor powder, many of which have been identified and described in detail. Particle size and particle size distribution (PSD) for example have a major influence on flowability but particle shape and other factors such as electrostatic charge can have a significant impact. Batch processing has traditionally dominated pharmaceutical production but in recent years, continuous manufacturing has grown in popularity due to the benefits it can deliver, e.g. improved and accelerated scale-up, enhanced process understanding and in particular real-time quality control. Monitoring raw material and product flow using in-line tools enables to process parameters to be adjusted real-time in response to any deviations detected. However, new technologies often come with new challenges. In continuous manufacturing, powder flow becomes even more critical if high product quality and a stable manufacturing process are to be maintained. Glidants, such as colloidal silicon dioxide, are often used to enhance flowability and can offer an efficient and economical alternative to granulation. However, use of this material in a continuous process can be challenging due to its low bulk density and poor feeding capability. The webinar will provide an introduction to glidant materials and how their impact on flowability of blends has been successfully evaluated using the FT4 Powder Rheometer. Speaker - Marek Lachmann | Business Development Manager | Chemische Fabrik Budenheim KG

麥克儀器公司是提供材料表征解決方案的全球領(lǐng)導(dǎo)廠商，在密度、比表面積及孔隙度、粒度及粒形、粉體表征、催化劑表征及工藝開發(fā)等五個核心領(lǐng)域擁有儀器和應(yīng)用技術(shù)。

麥克儀器公司成立于1962年，總部位于美國佐治亞州諾克羅斯，在全球擁有400多名員工。公司同時具備豐富的科學(xué)知識庫和內(nèi)部生產(chǎn)制造，為石油加工、石化產(chǎn)品和催化劑、食品和制藥等多個行業(yè)，以及下一代材料例如石墨烯、MOF材料、納米催化劑和沸石等表征提供高性能產(chǎn)品。公司設(shè)有Particle Testing Authority（PTA）實驗室,可提供商業(yè)測試服務(wù)。

戰(zhàn)略收購富瑞曼科技有限公司（Freeman Technology Ltd）和PID公司(PID Eng & Tech)，也反映公司一直致力于在粉體和催化等工業(yè)關(guān)鍵領(lǐng)域提供優(yōu)化、集成的解決方案。