動物無創全身體積描記系統/無創型動物肺功能檢測儀

WBP清醒無約束動物氣道高反應檢測系統 (Conscious， Unrestrained， Non-invasive)

?無須麻醉的無創檢測方法，動物清醒并可自由活動；

?操作簡單方便，可同時檢測數十只動物，適合于大量篩選實驗；

?尤其適用于長期跟蹤研究，同只動物多次重復實驗；

?提供呼吸速率、潮氣量、呼氣峰值、吸氣峰值、Penh等參數；

?提供從嚙齒類到非人靈長類動物的各種全身體積描記器。

無創型動物肺功能檢測系統/全身體積描記器

Whole body plethysmography is an application whereby ventilatory parameters are measured while the subject is conscious and unrestrained. By the use of bias airflow supplies， CO2 levels， temperature and humidity are maintained at normal levels enabling measurements to be made over several hours.

During inspiration there is a slight net pressure rise within theplethysmograph due to increased temperature and humidity of the air as it enters the subject’s lungs (gas conditioning). During normal breathing， this pressure difference is directly proportional to the respiratory pattern of the subject， allowing the researcher to measure respiratory rate and tidal volume， in accordance with ICH S7 Guidelines.

The system is commonly used in airway hyper-reactivity studieswhere， in addition to changes in ventilatory parameters， valuable data can obtained

by quantifying changes in the shape of the respiratory waveform， e.g.， Penh. However， it should be noted that when bronchoconstriction is present，

the respiratory signal is dominated by the effects of gas compression and therefore exact measures of tidal volume can not be determined.

Parameters Measured

· Breathing frequency

· Tidal volume (during normal breathing)

· Minute volume

· Penh (enhanced pause)

· Inspiration time

· Expiration time

· Peak inspiratory flow

· Peak expiratory flow

· Explanation and more parameters

Features

· Non-invasive

· Real time tidal volume measurement using multiple compensation factors (e.g. Epstein & Epstein， Drorbaugh & Fenn)

· Real time environmental monitoring (atmospheric pressure， temperature， humidity)

· Subject is unrestrained and conscious

· No anaesthesia

· Range of species including guinea pigs， rats and mice

· Chronic and long term use

· Measurement during aerosol challenge

·Up to sixteen animals measured simultaneously

· Optional body temperature measurement through telemetry

Uses

· Airway hyper-reactivity models

· Late phase response studies

· Chronic studies

· Drug screening

· Toxicology

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